The kit allows the identification of 5 mutations in DPYD gene associated to clinically relevant adverse event to the chemioterapic agent
Mutations:
c.1905+1G>A
c.1679T>G
c.2846A>T
c.1129–5923C>G (variante in linkage disequilibrium con c.1236G>A)
c.2194G>A
The kit allows the detection and identification of five allelic variants of the UGT1A1 gene associated with severe toxicity following administration of irinotecan, a drug used in cancer treatment. Furthermore, these same variants are associated with altered bilirubin metabolism in Gilbert’s syndrome. Protocol applicable on the OMNIA system for extraction and PCR set-up.
Detected variants: *1, *28, *36, *37, *6
The kit allows the identification of three allelic variants of UGT1A1 gene, associated to severe toxicity during the administration of irinotecan, an anti-tumoral drug.
In addition, the same variants are associated to altered metabolism of bilirubin in Gilbert’s syndrome.
Variants:
*1
*28
*36
*37
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